Blastocyst-Like Structures Generated From Human Pluripotent Stem Cells
Abstract
Human blastoids provide a readily accessible, scalable, versatile and perturbable alternative to blastocysts for studying early human development, understanding early pregnancy loss and gaining insights into early developmental defects.
Schematic Summary
Human blastoid formation from naive human PSCs and their potential applications
Citation
Leqian Yu#, Yulei Wei#, Jialei Duan#, Daniel A. Schmitz, Masahiro Sakurai, Lei Wang, Kunhua Wang, Shuhua Zhao, Gary C. Hon*, Jun Wu* (2021). Blastocyst-like structures generated from human pluripotent stem cells. Nature 591, 620–626.
DOI: 10.1038/s41586-021-03356-y